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Ferroportin (FPN), the only known cellular iron efflux protein, directly reduces intracellular iron levels to inhibit ferroptosis (Bao et al., 2021)

Alpha-lipoic acid is essential for the function of two major enzyme complexes within this cycle: pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase

In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)