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2 Estrogen is a pleiotropic factor in the hallmarks of aging As a result of modern medicine and prolonged life expectancy, humans can spend more than a third of their lives in the post-reproductive stage, when sex steroid hormone levels markedly decrease (Howdon and Rice, 2018

Qualifying patients (n = 51) were allocated to placebo, 25 or 100 mg losartan, or 20 mg enalapril

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