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However, the DHODH potent inhibitors, Leflunomide (LFM) and Brequinar (BRQ), which suppressed the tumor growth of GPX4 low xenografts 47 , have a negligible effect on VKD carboxylation (Fig

However, like any potent treatment, GH therapy must be carefully managed to avoid potential side effects and ensure optimal outcomes

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As discussed previously, a tentative example of selective effect would be modulation of S1PR2 in astrocytes, which seems to be linked to glutamate recycling and mitochondrial metabolism (116), both promising mechanisms to ameliorate excitotoxic synaptopathy