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The Evidence Base: What Human and Animal Studies Actually Show Translating rodent data to human protocols requires caution, but the MOTS-c literature offers enough cross-species convergence to draw meaningful clinical inferences

PGPIPN treatment significantly diminished fat accumulations of mice livers in PGPIPN I, II and III groups in a dose-dependent manner (Figure 5 and Table 1)

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Osteoblasts and osteoclasts functions are regulated by a system of neuropeptides from the central nervous system, which helps maintain the balance between bone formation and bone resorption (277)