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Your body uses B12 to build healthy blood cells and proteins and to metabolize fats and carbohydrates

B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers

Not everyone needs combination protocols

Only five participants were recruited for the severe renal impairment group instead of the seven that were planned because of recruitment being paused due to restrictions imposed by the coronavirus 2019 (COVID-19) pandemic