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It has a score of 1 on the Environmental Working Group (EWGs) skin-deep scale, indicating a low potential for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and use restrictions

A hypoxia-responsive polymer conjugate 5B was developed by coupling hyaluronic acid with BHQ3 moiety through azo bonds and encapsulated with DOX 122

For in vivo applications where extended half-life is not required, DES(1-3) IGF-1's higher potency allows researchers to achieve equivalent receptor activation at lower administered amounts

Furthermore, the reactivity of the disulfide bond can be modulated by steric hindrance