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In rat hindlimb ischemia models, this mechanism accelerated blood flow recovery and increased vessel density in oxygen-deprived tissues

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Ubiquitin-Proteasome System Ubiquitin is an evolutionarily conserved 76-amino acid moiety covalently tandemly linked to target protein components for degradation by the ubiquitin-proteasome system (UPS), and is required for degradation of about 80% intracellular proteins in eukaryotes (Pickart, 2001)