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(DAT, NET, and SERT) 10) By utilizing these transporters for its own uptake, amphetamine directly competes with endogenous dopamine, norepinephrine, and serotonin, thereby inhibiting their clearance from the synaptic cleft (Martin & Le, 2023)

The signaling pathway responsible for these effects appears to be cAMP/PKA/CREB, which in this study was shown to be negatively regulated by both NESF and NLP ( Figure 9 )