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Liver cirrhosis Cirrhosis is the advanced stage of liver fibrosis caused by long-term liver injury and is the main cause of death in CLDs (such as ALD, viral hepatitis, and MASLD) 70

LR3 has not been advanced into clinical development

Loss-of-function polymorphisms and a rare missense mutation in human CAMKK2 are associated with bipolar disorder, and genetic deletion of Camkk2 in mice causes bipolar-like behaviours similar to those in patients

of this proposed rule where we propose to modify two hybrid measures in the Hospital IQR Programthe Hybrid Hospital-Wide All-Cause Risk Standardized Mortality measure and the Hybrid Hospital-Wide All-Cause Risk Standardized Readmission measure