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Peptide Sciences Applications in Research As a molecular probe to study NNMT function, regulation, and downstream metabolic pathways To investigate metabolic flux , methylation dynamics, NAD salvage, and related bioenergetic phenomena In cellular assays , to test effects of NNMT inhibition on gene expression, metabolite profiling, or metabolic phenotypes In animal / ex vivo experiments for mechanistic elucidation of metabolic regulation (e.g

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In contrast, macrophages, though abundant in inflamed colons, did not show significant changes in Tnf or Nos2 expression under Gepon treatment, suggesting selective effects on monocytes and granulocytes rather than broad suppression of all myeloid subsets