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MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome that improves cellular energy metabolism, insulin sensitivity, and exercise capacity through AMPK activation and metabolic regulation

It has been approved for use in psoriatic arthritis (PsA) in the United States based on the Golimumab-Randomized Evaluation of Safety and Efficacy in Subjects With Psoriatic Arthritis Using a Human Anti-TNF Monoclonal Antibody (GO-REVEAL) trial

The serious gastrointestinal side effects of long-term administration of NSAIDs including ibuprofen, limit their clinical applicability [17]

Photo credit: Denver Water This was a big change in how we not only managed the pH, but how we ran our pumps, analyzers, and controls