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Because of its multifunctional protective properties, Humanin has emerged as a promising candidate for therapeutic development in age-associated and degenerative diseases

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Without proper care, the weakened TFCC remains susceptible to further damage, which can worsen the existing injury and prolong recovery

Besides, reactive glial cells, members of the NVU, are likely to contribute to the permeability of the BBB observed in cerebral hypoxia through downregulation of paracellular proteins such as Claudin-5 (CLDN5), occludin, and ZO-1 (Obermeier et al., 2013)