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sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

On the other hand, Woitke et al., 2017), indicating failure to compensate for the cognitive deficits

These investigations occur exclusively in controlled, non-clinical in-vitro environments

GLP-1 agonists work through GLP-1 receptors affecting appetite and glucose metabolism