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Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage

Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat skin in vitro correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes

B., Annabi, A., El Fazaa, S., & Gharbi, N

Induction of HO-1 expression in dendritic cells can maintain their immature state, further preventing polarization of T cells towards to inflammatory phase (T H 1 cells and T H 17 cells) and promoting T reg cell responses [45,46,47]