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A companion phase III trial reported a -10.9% reduction in visceral adipose tissue (a 21 cm decrease) in the tesamorelin group compared with -0.6% in the placebo group over the six-month efficacy phase, alongside significant improvements in trunk fat, waist circumference, and waist-hip ratio, with the authors concluding that tesamorelin reduces visceral fat by approximately 18% and improves body-image distress in HIV-infected patients with central fat accumulation, without significant side effects or disruption of glucose control

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Oral glutathione faces significant absorption challenges due to gastrointestinal degradation, with bioavailability estimates of 525%