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While safe at therapeuticdoses of up to 4 grams per day for adults, acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for some 56,000 emergency room visits, 2,600 hospitalizations and nearly 500 deaths annually

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In contrast, RNA-based therapies have gained interest as a promising modality in treating neurological diseases (Holm et al., 2022) and they demonstrate advantages over conventional small molecule pharmaceuticals

Notably, some research has emerged to suggest that ascorbic acid improved endothelial function in diabetic patients (Ashor et al., 1996)