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Ferroptosis: a trigger of proinflammatory state progression to immunogenicity in necroinflammatory disease

EpCAM and novel therapy EpCAM (CD326) is found only in the basolateral membrane of epithelial tissue while overexpressed throughout the cancerous tissue membrane, making this molecule a good candidate for targeting in the treatment of cancer [185]

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Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig