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The binding of the RGD motifs to the V integrins expressed in tumor endothelial cells induces the protease-mediated cleavage of the iRGD peptide, producing two peptides, namely, CRGDR/K and GPDC

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Glutathione IV is paired with chemical peels (glycolic or TCA), low-fluence Q-switched Nd:YAG laser toning, medical-grade topical regimens (vitamin C, niacinamide, tretinoin) and tranexamic acid where indicated

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