130 For example, a popular dual agonist, tirzepatide (brand name Mounjaro), activates both GLP-1 and GIPR
The advisory notes these products are being marketed online and on social media for anti-aging, weight loss, injury recovery, sleep, mental focus and general wellness, and that Health Canada has already seized several of them
Studies suggest it may help with neurodegenerative diseases through brain-safe effects, heart disease through vascular health gains, body disorders through effects on insulin response and body function, and cancer prevention through downregulation of cancer-related genes (though this needs more research)
Pathways regulating ferroptosis in AD Kelch-like ECH-associated protein 1 (Keap1)/Nrf2)/antioxidant response element (ARE) pathway In cellular defense against oxidative stress, the Keap1/Nrf2/ARE signaling pathway regulates the expression of various proteins involved in detoxification and antioxidant defense, positioning it as a potential target for AD treatment (61)
