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Protective interventions aim to reduce lipid peroxidation by enhancing GPX4 activity or introducing exogenous lipophilic antioxidants, while inhibitory tactics directly counter IR-induced pro-ferroptotic iron and lipid metabolic pathways

It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat

Anionic (AL) and cationic (CL) hydrogenated lecithin-based liposomes were obtained as GHK-Cu skin delivery systems using the thin-film hydration method combined with freeze-thaw cycles and the extrusion process