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To elucidate the mechanism behind the beneficial effects of glutathione, further studies that examine the incorporation of orally administrated glutathione into the liver and the effects on the host redox system using stable isotope-labeled glutathione and animal models are required

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Badamchian reported that a median lethal dose of LPS in rats led to a significant reduction of blood T4, and administration of T4 immediately following the dose of LPS in mice significantly reduced mortality rates (P = 0.024) and lowered the levels of inflammatory cytokines in the blood