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The release of cytotoxic proteins and toxic oxygen radicals further damages the respiratory epithelium, and the bronchial tree becomes hypersensitive

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In addition, since some studies have also recorded failure in antioxidant supplementation efficacy, optimal design of clinical trials in terms of targeted delivery of antioxidants, clinical pathology and concentration dependent dosage schedule is needed to go ahead in the knowledge and future application of this kind of treatment in CIPN (Kamat et al., 2008)