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The N-terminal 13-amino-acid extension and the E3R substitution in LR3 reduce binding affinity to IGFBPs by approximately one to two orders of magnitude, increasing the free IGF-1 fraction available to bind the type 1 IGF receptor at any given total concentration

Ferroptosis directly promotes immunogenic cell death, a process in which cells release ATP and high mobility group box 1 proteins, while exposing calreticulin on their surface

h , Volcano plots of the fold change in mitochondrial metabolite abundance (log 2 ) versus P values (-log) from HEK-293T SLC25A39 knockout cell line expressing a vector control or SLC25A40 cDNA

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