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Other metals which are present in the environment as industrial pollutants are not able to generate free radicals by shuttling between contiguous oxidation states but it is known that organisms exposed either in their natural environment or in toxicological experiments show signs of oxidative stress, and some metals, such as As, Cd and Hg, are also carcinogenic to humans

Caution should be taken with those that have megaloblastic anemia as B12 can reduce potassium levels in the blood

This makes it of particular interest in studies targeting body recomposition and long-term metabolic efficiency, where muscle retention is critical for sustaining basal metabolic rate