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Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7

The findings of this study suggest that a history of premature cardiovascular disease in male relatives (such as father, brother, or son) may serve as a protective factor against smoking intensity in adult males

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