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A calmer gut means a calmer immune system

It is noteworthy that long-term HFD consumption may differentially regulate NF-B activity in hepatocytes (inhibition) and Kupffer cells (activation by lipopolysaccharide)

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These seemingly paradoxical effects may be one explanation for why patients with G6PD-d display increased susceptibility to infection indicative of an impaired immune response, while also displaying increased autoimmunity and inflammation indicative of an overactive immune system 13