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For example, mutations of PINK1 (PTEN-induced kinase 1), a key regulator of mitochondrial function and structure, have been linked to AD and PD [36]

Therefore, in order to more effectively correct sleep or circadian abnormalities in psychiatric disorders, it is necessary to apply both an appropriate dose and an appropriate dosing time, according to the purpose of melatonin supplements [84, 85]

L.Martnez-GarcaA.Jimnez-HernndezE.et al (2020)