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Nicotine reduces the activity of testicular androgenic enzymes, plasma testosterone concentration, and testicular tissue

Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)

But opponents say raising the legal age to 21 would hurt small businesses, reduce tax revenue, and violate the personal freedom of young adults who are legally able to vote and join the military