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Acknowledgements The authors are thankful to the Plant Physiology and Molecular Systematics and Applied Ethnobotany Lab

IGF-1 LR3: mechanism and evidence base IGF-1 LR3 (insulin-like growth factor 1 long arginine 3) is an 83-amino-acid synthetic analogue of human IGF-1 in which glutamic acid at position 3 is replaced with arginine and an additional 13-amino-acid extension is appended to the N-terminus

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Furthermore, elevated uric acid observed in SCC47 compared to Detroit562 indicates active purine catabolism, suggesting differences in proliferation rates or preferential recycling of purines back to guanosine monophosphate (GMP) and inosine monophosphate (IMP) 32