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Noonan EJ, Place RF, Giardina C, Hightower LE: Hsp70B' regulation and function

Quercetin and other flavonoids are known to behave as mild prooxidants resulting in the upregulation of protective genes, such antioxidant enzymes, glutathione, and cytoprotective enzyme Heme Oxygenase HO-1 mediated by activation of the Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor upregulating antioxidant response, expression of antioxidant enzymes, and cytoprotective proteins (Ma and He 2012)

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It enhances endogenous CBD levels and GABAergic transmission, thereby improving the balance between inhibitory and excitatory neurotransmission (164)