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Pulmonary drug delivery for treatments targeting the respiratory tract offers many benefits over other routes of delivery, including higher drug concentration at the site of action, reduced overall dosage and, importantly, improved accessibility in low-resource settings 7,8,9

In particular, vitamin D deficiency was identified to negatively regulate microRNA-196b- 5p (regulatory microRNA that helps maintain normal granulosa cell growth and survival) which negatively affected its target genes operating in granulosa cells

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For MI, curcumin can inhibit NLRP3 inflammasomes by reducing oxidative stress, mitochondrial dysfunction and reactive oxygen species (ROS), and inhibits CRP production in aldosterone-induced rat vascular smooth muscle cells through the ROS-ERK1/2 signaling pathway