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Supplementation is most beneficial when combined with a healthy lifestyle

In an alkali-burn rat model with companion HUVEC work, Huang and colleagues reported that BPC-157 upregulated VEGF-A expression in wounded skin and accelerated tube formation in vitro, attributing effects to ERK1/2 signaling a pathway-level overlap but not an exact replication of the VEGFR2-internalization finding (Huang et al., 2015)

A 2018 review described BPC-157 in relation to standard angiogenic growth factors, discussing tendon, ligament and bone healing models and angiogenic effects

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