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E-cigarettes affect digestion through: Rapid nicotine delivery to the bloodstream Higher nicotine concentrations in some products (up to 50mg/mL) Propylene glycol and vegetable glycerin, which may affect gut function Flavorings and additives with potential digestive effects These factors can trigger or worsen IBS symptoms in some users, including alternating constipation and diarrhea

So, what will the OTC pathway look like, and if created, will it be a viable alternative to the existing PMTA process for the thousands of small businesses that make up the ENDS industry

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