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Headache 57 , 3746 (2017)

A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

Seko Y, Sumida Y, Tanaka S, et al

This result confirmed that (1) the assay detects endogenous LOXs activity in cells, (2) extracellular incorporation of BHZ corresponds to the presence of total activity of LOXs in the extracellular space, and 3) LOXL2 depletion results in a significant loss of total LOXs activity in HASMC