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In a systematic review and meta-analysis, Hunter et al

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I will revisit my position when there is an FDA approved E-cigarette cessation product. But smokers cannot wait for the FDA to approve products that are widely shown to help people quit cigarettesnot while there is a US smoking epidemic that tragically claims the lives of 480,000 people every year

As shown in Supplementary Table S1 online, the full range of available LD50 values in different animal species is taken into account as a risk function assuming a normal distribution for BMDL10 rather than that a single value is entered into the calculation (except methamphetamine and MDMA for which only one value was available in the literature)