Although the interaction between these compounds has not been classified as synergistic, it is relatively strong and after the verification by different types of tests or in vivo studies (Vitale et al., 2005) it might change character, as it was observed previously in the case of caspofungin/amphotericin B combination used against C
Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation
Conventional anti-folates such as aminopterin, pralatrexate, methotrexate (MTX), and pemetrexed (PMX) are the most prevalent types of DHFR inhibitors
To evaluate whether these changes will affect the metabolic profiles induced by hemin, we measured SAM and SAH levels, where SAM accumulation by hemin was reduced by DMF treatment (Fig