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A 2021 review confirmed no clinical trials targeting NNMT had been reported [5], and MOTS-c likewise has no large human efficacy trial proving it works as a fat-loss therapy

Low levels of IF can also be caused by diseases such as Crohns disease or celiac disease, surgery involving the stomach and/or small intestine, or a strict vegetarian diet

In some embodiments, the formulations or compositions described herein have a pH and osmolarity as described herein, and have a concentration of active pharmaceutical ingredient between about 0.01-about 20%, between about 0.01-about 10%, between about 0.01-about 7%, between about 0.01-5%, between about 0.01-about 3%, between about 0.01-about 2% of the active ingredient by weight of the formulation or composition