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LAT1, which is encoded by slc7a5, serves as a sodium-independent amino acid exchanger that facilitates the transport of large neutral amino acids

DNase I and/or EDTA are included in the cell medium to reduce any cell aggregation to a minimum

The addition of isoliquiritigenin to human chondrocytes resulted in an increase in cell viability and a reduction in apoptosis

The safety profile was consistent with GLP-1 receptor agonists, with gastrointestinal events including nausea, vomiting, diarrhea, constipation, or abdominal pain, being most common (affecting 79.6% in the cagrilintidesemaglutide group and 39.9% in the placebo group) but mainly transient and mild to moderate in severity