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The glutathione redox cycle, demonstrating the inter-conversion of oxidized and reduced glutathione GLUTATHIONE AND HUMAN PIGMENTATION : Melanin in human skin is a polymer of various indole compounds synthesized from L-tyrosine by the RaperMason pathway of melanogenesis [Figure - 2] with tyrosinase being the rate limiting enzyme

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www.thyroid.org Caturegli P, De Remigis A, Rose NR (2014) Hashimoto thyroiditis: clinical and diagnostic criteria

The four-pathway approach activates mechanisms that single or dual agonists cannot reach, potentially overcoming resistance that develops with prolonged use of less comprehensive compounds