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These can include gastrointestinal issues, skin rashes, or allergic reactions in rare cases

Cisplatin activates NOX (nicotinamide adenine dinucleotide phosphate oxidase) (especially the NOX3 isoform) (Ramkumar et al., 2021), xanthine oxidase (XO) (Tan and Vlajkovic, 2023), and increases the production of superoxide radicals

Databases such as PubMed, Scopus, and Web of Science were utilized, employing relevant keywords related to the ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. The goal was to extract qualitative and quantitative data from studies that investigate gut microbiota composition, assess inflammatory markers, and evaluate the therapeutic outcomes of interventions targeting the microbiome