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SAG also reduced GSSG levels, lipid peroxidation and H 2 O 2 liver levels

This result clearly suggests that the detected end-product incorporated both 15 N atoms from the six-membered ring of the purine skeleton of UA

This event triggers the primed microglia to assemble functional NLRP3 inflammasomes, which subsequently catalyze the maturation and substantial release of IL-1, thereby further amplifying the inflammatory cascade (Vezzani and Baram, 2007)