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Thus, GSH plays the role of a mediator in crucial cellular processes, such as cell cycle progression and programmed cell death ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by -glutamylcysteine synthetase (-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) (Noctor et al., 2002, 2012

Materials and Methods Study population Ninety individuals of different ages and from both sexes were included in this study that was carried out during the period from December 2021 until May 2022 where 5 mL of venous blood samples were collected from the study participants after signing consent to participate in the study and participants were divided into two groups: Group A: It consisted of 45 patients with COVID-19 diagnosed according to the Iraqi National Guidelines for the diagnosis and treatment of COVID-19 and the interim World Health Organization (WHO) guidelines of polymerase chain reaction (PCR) assay of nasal and pharyngeal swabs in Al-Shifa hospital in Kirkuk city

Water follows the electrolytes, leading to cell shrinkage, a hallmark of eryptosis [90]