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(148) noted in their 2023 systematic review that the prevalence of HHcy in ESRD patients is approximately 85%100%, significantly increasing cardiovascular event risk

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In these cases, IV delivery is the most practical route for reaching therapeutic plasma concentrations quickly

The study further hypothesized that PZQ facilitated the opening of more channels for current to flow leading to the disruption of 1/ interaction in these channels resulting in disruption of Ca 2+ homeostasis ( Due to the shortcomings of the drugs listed in Table 1, researchers have resorted to the use of drug delivery technologies such as nanotechnology to provide more targeted therapies to all stages of the Schistosoma parasite such that drugs can be more effective in treating the immature forms of the parasite