The increase in BDNF and IGF-1 levels in response to physical activity is especially important, as these factors help new neurons survive and integrate into existing networks, boost synaptic plasticity, and lead to better cognitive function and mood
Decreased striatal dopamine synthesis capacity with age has not been consistently observed, while less striatal dopamine D2 receptor displacement by endogenous dopamine after d-amphetamine administration was associated with advancing age [145,146,147,148,149,150]
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