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The insulin-like growth factor (IGF)-I E-peptides are required for isoform-specific gene expression and muscle hypertrophy after local IGF-I production

High concentrations of extracellular ATP, a critical purinergic signal released during tissue injury, activate the P2X7 receptor, thereby promoting NLRP3 inflammasome activation and compromising endothelial cell integrity, further aggravating neuroinflammation (131)

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