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The consequent impact on spermatogenesis is profound, resulting in significantly reduced sperm count, motility, and increased sperm abnormalities and DNA fragmentation, which collectively impair fertilization potential and embryo development 11

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283 Mitochondria in aging and oxidative stress Harman proposed the free radical theory of aging in the 1950s, which hypothesized that the increase of free radicals, especially oxygen free radicals, would induce oxidative stress, causing damage to a variety of bioactive substances and accelerating aging

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