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While preservative-free saline is FDA-labeled, many U.S

This can be useful as a preventative measure and a complementary treatment for conditions typically associated with aging, such as cancer, Alzheimers, chronic obstructive lung disease (COPD), nephropathy, and retinopathy

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In addition, the limit of volumes (25250 l) for nasal administration, influence of nasal pathologic conditions such as rhinitis and common cold on the absorption, and potential for nasal irritation by drug administration in the nasal cavity, are significant factors governing in the choice of the nasal route for drug application (Ozsoy et al., 2009