We also saw that with placebo supplementation, the levels of oxidized GSH significantly increased, while levels of reduced GSH significantly decreased in all blood components
Collectively, these studies demonstrate that Sch B and SCF exhibit dose-dependent toxicity, primarily manifesting as hepatomegaly, oxidative stress, and dysregulated lipid metabolism
Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways
MRP1, multidrug resistance-associated protein 1