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Glutathione exists in reduced (GSH) and oxidized (GSSG) states, with the reduced form (GSH) predominating

doi: 10.1016/S0002-9440(10)63858-8 82 WalleniusK.SjgrenK.PengX

Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition