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The presence of an expanded polyQ tract in proteins leads to a self-association that competes with polyQ-mediated interaction with beclin-1 and impairs autophagy in vitro (as observed for ATXN3) and in vivo (as observed for huntingtin), at least in conditions of starvation [85]

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Research-Grade 5-Amino-1MQ and Purity Standards Importance of Purity Verification Researchers searching for research compounds prioritize purity standards and analytical testing before purchasing laboratory materials